Advertisers large and small will always need big, splashy brand-building ads on high-traffic Web sites –- look at the growth in native advertising for proof. But they’ll also always need conversions for demonstrable ROI. Fortunately, these two needs aren’t bound by the same set of rules. While high-profile native ads are often confined to the comScore 500, the audience viewing these ads often ventures beyond the most-trafficked sites, creating a huge opportunity to reach the same targets in the mid and long tail. Advertisers are missing the opportunity because the early RTB innovators focused on the comScore 250, leaving the mid and long tail under-served.